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Article

Substrate-specific modulation of CYP3A4 activity by genetic variants of cytochrome P450 oxidoreductase.

Pharmacogenetics and genomics - 1 Oct 2010

Agrawal Vishal, Choi Ji Ha, Giacomini Kathleen M, Miller Walter L

Abstract excerpt

OBJECTIVES: CYP3A4 receives electrons from P450 oxidoreductase (POR) to metabolize about 50% of clinically used drugs. There is substantial inter-individual variation in CYP3A4 catalytic activity that is not explained by CYP3A4 genetic variants. CYP3A4 is flexible and distensible, permitting it to accommodate substrates varying in shape and size. To elucidate the mechanisms of variability in CYP3A4 catalysis, we...

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Identifiers

PMID: 20697309
DOI: 10.1097/FPC.0b013e32833e0cb5
PMCID: PMC2940949

Genes

POR

Variants

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