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Article

Functional characterization of eight human CYP1A2 variants: the role of cytochrome b5.

Pharmacogenetics and genomics - 1 Feb 2013

Palma Bernardo B, Silva E Sousa Marta, Urban Phillipe, Rueff José, Kranendonk Michel

Abstract excerpt

BACKGROUND: Interindividual variability in cytochrome P450 (CYP)-mediated xenobiotic metabolism is extensive. CYP metabolism requires two electrons, which can be donated by NADPH cytochrome P450 oxidoreductase (CYPOR) and/or cytochrome b5 (b5). Although substantial number of studies have reported on the function and effect of b5 in CYP-mediated catalysis, its mode of action is still not fully understood....

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Source

Identifiers

PMID: 23295917
DOI: 10.1097/FPC.0b013e32835c2ddf

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BTC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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