Article
The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex.
Molecular cell - 1 Feb 2001
Cavalli V, Vilbois F, Corti M, Marcote M J, Tamura K, Karin M, Arkinstall S, Gruenberg J
Abstract excerpt
Early endocytic membrane traffic is regulated by the small GTPase Rab5, which cycles between GTP- and GDP-bound states as well as between membrane and cytosol. The latter cycle depends on GDI, which functions as a Rab vehicle in the aqueous environment of the cytosol. Here, we report that formation of the GDI:Rab5 complex is stimulated by a cytosolic factor that we purified and then identified as p38 MAPK. We...
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