Article
The KDEL receptor modulates the endoplasmic reticulum stress response through mitogen-activated protein kinase signaling cascades.
The Journal of biological chemistry - 5 Sept 2003
Yamamoto Katsushi, Hamada Hiromichi, Shinkai Hiroshi, Kohno Yoichi, Koseki Haruhiko, Aoe Tomohiko
Abstract excerpt
The accumulation of misfolded proteins in the endoplasmic reticulum (ER) evokes the ER stress response. The resultant outcomes are cytoprotective but also proapoptotic. ER chaperones and misfolded proteins exit to the secretory pathway and are retrieved to the ER, during which process the KDEL receptor plays a significant role. Using an expression of a mutant KDEL receptor that lacks the ability for ligand...
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