VAMP4 cycles from the cell surface to the trans-Golgi network via sorting and recycling endosomes.

doi:10.1242/jcs.03387

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Article

VAMP4 cycles from the cell surface to the trans-Golgi network via sorting and recycling endosomes.

Journal of cell science - 15 Mar 2007

Tran Ton Hoai Thi, Zeng Qi, Hong Wanjin

Abstract excerpt

VAMP4 is enriched in the trans-Golgi network (TGN) and functions in traffic from the early and recycling endosomes to the TGN, but its trafficking itinerary is unknown. Cells stably expressing TGN-enriched VAMP4 C-terminally-tagged with EGFP (VAMP4-EGFP) are able to internalize and transport EGFP antibody efficiently to the TGN, suggesting that VAMP4-EGFP cycles between the cell surface and the TGN. The...

Topics

Animals
Cell Line
Cell Membrane
Chlorocebus aethiops
Endocytosis
Endosomes
Golgi Apparatus
Green Fluorescent Proteins
Macrolides
Mutation
Protein Sorting Signals
Protein Transport
R-SNARE Proteins
Rats
Recombinant Fusion Proteins

Source

Open in PubMed

Identifiers

PMID: 17327277
DOI: 10.1242/jcs.03387

Genes

VAMP4
VAMP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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