Article
Mechanisms regulating the nuclear translocation of p38 MAP kinase.
Journal of cellular biochemistry - 15 Aug 2010
Gong Xiaowei, Ming Xiaoyan, Deng Peng, Jiang Yong
Abstract excerpt
p38 mitogen-activated protein kinase (MAPK) is of fundamental importance in a cell's response to environmental stresses, cytokines and DNA damage. p38 resides in the cytoplasm of resting cells, and translocates into the nucleus upon activation, yet the exact mechanisms remain largely unclear. We show here that the phosphorylation-dependent nuclear translocation of p38 is a common phenomenon when cells are...
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