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Article

Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers.

Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2002

Bannon Michael J, Pruetz Barb, Manning-Bog Amy B, Whitty Christopher J, Michelhaugh Sharon K, Sacchetti Paola, Granneman James G, Mash Deborah C, Schmidt Carl J

Abstract excerpt

Chronic exposure to cocaine induces long-term adaptations that are likely to involve changes in transcription factor expression. This possibility has not been examined in the cocaine-exposed human brain. The transcription factor nurr1 is highly expressed in rodent midbrain dopamine neurons and is essential for their proper phenotypic development. Here we show that human NURR1 gene expression is robust within...

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Identifiers

PMID: 11959923
DOI: 10.1073/pnas.092654299
PMCID: PMC122957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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