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Retinoblastoma: from discovery to clinical management

27 May 2021

Abstract excerpt

The retinoblastoma gene (RB1) was the first tumour suppressor cloned; the role of its protein product (RB) as the principal driver of the G1 checkpoint in cell cycle control has been extensively studied. However, many other RB functions are continuously reported. Its role in senescence, DNA repair and apoptosis, among others, is indications of the significance of RB in a vast network of cellular interactions,...

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PMID: 34042282
DOI: 10.1111/febs.16035

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