Article
The Biology of Retinoblastoma.
Progress in molecular biology and translational science - 1 Jan 2015
Mendoza Pia R, Grossniklaus Hans E
Abstract excerpt
Retinoblastoma, the most common primary intraocular cancer of childhood, is a malignancy arising in the developing retina. Tumor formation usually begins with mutation in both alleles of the retinoblastoma tumor suppressor gene RB1, followed by a series of other genetic alterations that correlate with the clinical stage and pathologic findings of the tumor. Analysis of sporadic and heritable retinoblastoma led to...
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