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DNMT1/PKR double knockdowned HepG2 (HepG2-DP) cells have high hepatic function and differentiation ability

2022-06-09

Abstract excerpt

HepG2 cells are widely used as a human hepatocytes model, but their functions, including drug metabolism, are inferior to primary hepatocytes. We previously reported that the hepatic gene expressions in HepG2 cells were upregulated by treatment with zebularine, which is an inhibitor of DNA methylation, through the inhibition of both DNA methyltransferase 1 (DNMT1) and double-stranded RNA-dependent protein kinase (...

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Literature Corpus work
a0ec4233-d330-5b78-a8bf-1e452a9bdf9d
DOI
10.21203/rs.3.rs-1709947/v1
Open publication

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