Variable expression of hepatic genes in different liver tumor cell lines: conclusions for drug testing

Abstract excerpt

Introduction Drug discovery and development is a complex, multi-stage process that often spans over a decade and involves high costs and low success rates. Preclinical testing, particularly the assessment of drug-induced liver injury, plays a crucial role in identifying safe and effective therapeutics before clinical trials. In vitro models based on hepatic cell lines are commonly used to study hepatotoxicity,...

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