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Article

Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis.

Current biology : CB - 6 Feb 2001

Gurley K E, Kemp C J

Abstract excerpt

The gene product mutated in ataxia telangiectasia, ATM, is a ubiquitously expressed 370 kDa protein kinase that is a key mediator of the cellular response to DNA damage [1]. ATM-deficient cells are radiosensitive and show impaired cell cycle arrest and increased chromosome breaks in response to ionizing radiation. ATM is a member of the phosphatidylinositol-3-kinase (PI3K)-related protein kinase superfamily,...

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Source

Identifiers

PMID: 11231155
DOI: 10.1016/s0960-9822(01)00048-3

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis.PMID 11231155Read ↗

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DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during NeurogenesisSemantic proximity Read ↗

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Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice.Semantic proximity Read ↗

Atm-null mice exhibit enhanced radiation-induced birth defects and a hybrid form of embryonic programmed cell death indicating a teratological suppressor function for ATM.Semantic proximity Read ↗

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