Article
Misexpression of IGF-I in the mouse lens expands the transitional zone and perturbs lens polarization.
Mechanisms of development - 1 Mar 2001
Shirke S, Faber S C, Hallem E, Makarenkova H P, Robinson M L, Overbeek P A, Lang R A
Abstract excerpt
Insulin-like growth factor-I (IGF-I) has been implicated as a regulator of lens development. Experiments performed in the chick have indicated that IGF-I can stimulate lens fiber cell differentiation and may be involved in controlling lens polarization. To assess IGF-I activity on mammalian lens cells in vivo, we generated transgenic mice in which this factor was overexpressed from the alphaA-crystallin promoter....
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