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Platelet-derived growth factor-A regulates lung fibroblast S-phase entry through p27kip1 and FoxO3a

1 Jan 2013

Abstract excerpt

BACKGROUND: Secondary pulmonary alveolar septal formation requires platelet derived growth factor (PDGF-A) and platelet derived growth factor receptor-alpha (PDGFRα), and their regulation influences alveolar septal areal density and thickness. Insufficient PDGFRα expression in lung fibroblasts (LF) results in failed septation. METHODS: Mice in which the endogenous PDGFRα-gene regulates expression of the green...

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PMID: 23819440
DOI: 10.1186/1465-9921-14-68

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