Article
AP-2α is required after lens vesicle formation to maintain lens integrity.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Oct 2014
Kerr Christine L, Zaveri Mizna A, Robinson Michael L, Williams Trevor, West-Mays Judith A
Abstract excerpt
BACKGROUND: Transcription factors are critical in regulating lens development. The AP-2 family of transcription factors functions in differentiation, cell growth and apoptosis, and in lens and eye development. AP-2α, in particular, is important in early lens development, and when conditionally deleted at the placode stage defective separation of the lens vesicle from the surface ectoderm results. AP-2α's role...
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