Article
Enzymatic and nonenzymatic functions of viral RNA-dependent RNA polymerases within oligomeric arrays.
RNA (New York, N.Y.) - 1 Feb 2010
Spagnolo Jeannie F, Rossignol Evan, Bullitt Esther, Kirkegaard Karla
Abstract excerpt
Few antivirals are effective against positive-strand RNA viruses, primarily because the high error rate during replication of these viruses leads to the rapid development of drug resistance. One of the favored current targets for the development of antiviral compounds is the active site of viral...
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