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Article

Expression of interleukin-8 promotes neutrophil infiltration and genetic instability in mutatect tumors.

Neoplasia (New York, N.Y.) - 1 Jan 2000

Haqqani A S, Sandhu J K, Birnboim H C

Abstract excerpt

Neutrophils represent a potential source of genotoxic reactive oxygen and nitrogen species in the tumor microenvironment. Using Mutatect cell lines, which can form subcutaneous tumors in syngeneic C57BL/6 mice, we have previously established that the number of spontaneously infiltrating neutrophils correlates with the number of mutations at the hypoxanthine phosphoribosyltransferase (Hprt) locus. We now describe...

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Identifiers

PMID: 11228549
DOI: 10.1038/sj.neo.7900110
PMCID: PMC1508092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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