Article
Neutrophil Conversion to a Tumor-Killing Phenotype Underpins Effective Microbial Therapy.
Cancer research - 14 Apr 2023
Yam Andrew O, Bailey Jacqueline, Lin Francis, Jakovija Arnolda, Youlten Scott E, Counoupas Claudio, Gunzer Matthias, Bald Tobias, Woodruff Trent M, Triccas James A, Goldstein Leonard D, Gallego-Ortega David, Grey Shane T, Chtanova Tatyana
Abstract excerpt
The inflammatory microenvironment of solid tumors creates a protumorigenic milieu that resembles chronic inflammation akin to a subverted wound healing response. Here, we investigated the effect of converting the tumor microenvironment from a chronically inflamed state to one of acute microbial inflammation by injecting microbial bioparticles directly into tumors. Intratumoral microbial bioparticle injection led...
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