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Article

The potential role of neutrophils in promoting the metastatic phenotype of tumors releasing interleukin-8.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2004

De Larco Joseph E, Wuertz Beverly R K, Furcht Leo T

Abstract excerpt

In the last decade, several groups have shown a direct correlation between the inappropriate or ectopic release of interleukin (IL)-8 by tumor cells in vitro and their growth and metastatic potential using in vivo models of tumor growth. IL-8 is a potent neutrophil chemoattractant. Neutrophils, as "early responders" to wounds and infections, release enzymes to remodel the extracellular matrix of the tissues...

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Identifiers

PMID: 15297389
DOI: 10.1158/1078-0432.CCR-03-0760

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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