Article
Effect of dietary vitamin E on spontaneous or nitric oxide donor-induced mutations in a mouse tumor model.
Journal of the National Cancer Institute - 6 Sept 2000
Sandhu J K, Haqqani A S, Birnboim H C
Abstract excerpt
BACKGROUND: Vitamin E, an antioxidant, has been investigated for its effect on cancer incidence in humans, but no firm conclusions about a protective effect can be drawn from these studies. Recently, we reported a statistically significant correlation in the Mutatect mouse tumor model between the number of neutrophils and the frequency of mutation at the hypoxanthine phosphoribosyltransferase (hprt) locus. We...
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