Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neutrophils, nitric oxide synthase, and mutations in the mutatect murine tumor model.

The American journal of pathology - 1 Feb 2000

Sandhu J K, Privora H F, Wenckebach G, Birnboim H C

Abstract excerpt

Mutatect MN-11 is a tumor line that can be grown subcutaneously in syngeneic C57BL/6 mice. The frequency of spontaneously arising mutants at the hypoxanthine phosphoribosyltransferase (Hprt) locus was observed to be elevated as a result of in vivo growth. The objective of the present study was to identify factors in the tumor microenvironment that might explain this increase in mutant frequency (MF). When tumors...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dinoprostone
Share to Drug Combinations
Share to Fibrosarcoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Injections

Share to Injections, Subcutaneous

Share to Interleukin-8

Share to Nitric Oxide Synthase

Share to Nitric Oxide Synthase Type II

Source

Open in PubMed Open full text

Identifiers

PMID: 10666380
DOI: 10.1016/S0002-9440(10)64755-4
PMCID: PMC1850043

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neutrophils, nitric oxide synthase, and mutations in the mutatect murine tumor model.PMID 10666380Read ↗

Expression of interleukin-8 promotes neutrophil infiltration and genetic instability in mutatect tumors.Semantic proximity Read ↗

Dietary vitamin E affects neutrophil distribution and genetic instability in murine Mutatect tumors.Semantic proximity Read ↗

Constitutive expression of interleukin-8 by Mutatect cells markedly affects their tumor biology.Semantic proximity Read ↗

Effect of dietary vitamin E on spontaneous or nitric oxide donor-induced mutations in a mouse tumor model.Semantic proximity Read ↗

Dose-dependent effects of dietary alpha- and gamma-tocopherols on genetic instability in mouse Mutatect tumors.Semantic proximity Read ↗

Moderate hypermutability of a transgenic lacZ reporter gene in Myc-dependent inflammation-induced plasma cell tumors in mice.Semantic proximity Read ↗

The potential role of neutrophils in promoting the metastatic phenotype of tumors releasing interleukin-8.Semantic proximity Read ↗

Neutrophil-derived reactive oxygen species promote tumor colonization.Semantic proximity Read ↗

The 1996 Veylien Henderson Award of the Society of Toxicology of Canada. Current concepts: neutrophils and the activation of carcinogens in the breast and other organs.Semantic proximity Read ↗

Mutagenesis associated with nitric oxide production in macrophages.Semantic proximity Read ↗

Infiltration of neutrophils is required for acquisition of metastatic phenotype of benign murine fibrosarcoma cells: implication of inflammation-associated carcinogenesis and tumor progression.Semantic proximity Read ↗

Macrophage function in mice with a mutation at the microphthalmia (mi) locus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.