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Article

Dose-dependent effects of dietary alpha- and gamma-tocopherols on genetic instability in mouse Mutatect tumors.

Journal of the National Cancer Institute - 19 May 2004

Soo Catherine C-Y, Haqqani Arsalan S, Hidiroglou Nick, Swanson Joy E, Parker Robert S, Birnboim H Chaim

Abstract excerpt

Vitamin E in foodstuffs is a mixture of tocopherols. In mouse Mutatect tumors, a model designed to detect DNA mutations, the hypoxanthine phosphoribosyltransferase (Hprt) gene mutation frequency is associated with the number of tumor-infiltrating neutrophils and both are markedly decreased in mice fed high levels of alpha-tocopherol. Dietary alpha-tocopherol is also associated with a decrease in...

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Identifiers

PMID: 15150308
DOI: 10.1093/jnci/djh137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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