Article
Inhibition of growth of melanoma cells by CD95 (Fas/APO-1) gene transfer in vivo.
The Journal of investigative dermatology - 1 Dec 2000
Aragane Y, Maeda A, Cui C Y, Tezuka T, Kaneda Y, Schwarz T
Abstract excerpt
Interaction of CD95 ligand with its cognate receptor CD95 induces apoptotic cell death. Alterations in this pathway within tumor cells can result in escape from apoptosis and from immune surveillance. Melanoma cells recently were found to escape an immune attack via high expression of CD95 ligand, thereby inducing apoptosis of activated T lymphocytes. When screening four human melanoma cell lines for expression...
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