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Article

A ribozyme selected from variants of U6 snRNA promotes 2',5'-branch formation.

RNA (New York, N.Y.) - 1 Jan 2001

Tuschl T, Sharp P A, Bartel D P

Abstract excerpt

In vitro selection was used to sample SnRNA-related sequences for ribozyme activities, and several 2',5'-branch-forming ribozymes were isolated. One such ribozyme is highly dependent upon an 11-nt motif that contains a conserved U6 snRNA sequence (ACAGAGA-box) known to be important for pre-mRNA splicing. The ribozyme reaction is similar to the first step of splicing in that an internal 2'-hydroxyl of an unpaired...

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Identifiers

PMID: 11214178
DOI: 10.1017/s1355838201001510
PMCID: PMC1370066

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Source receipt: pubmed, retrieved 7 Sept 2026.

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