Article
Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) polymorphisms in susceptibility to bladder cancer: the influence of smoking.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 1997
Okkels H, Sigsgaard T, Wolf H, Autrup H
Abstract excerpt
Aromatic amines are involved in the etiology of bladder cancer. These compounds are acetylated by N-acetyltransferase 1 (NAT1) and 2 (NAT2), and epidemiological studies have shown that the slow NAT2 acetylator phenotype is associated with increased risk of bladder cancer and may be associated wit...
Topics
- Aged
- Aged, 80 and over
- Arylamine N-Acetyltransferase
- Case-Control Studies
- Colorectal Neoplasms
- Denmark
- Female
- Gene Frequency
- Genotype
- Humans
- Isoenzymes
- Male
- Middle Aged
- Phenotype
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length
- Risk Factors