Article
Male-to-female excess in diabetes diagnosed in early adulthood is not specific for the immune-mediated form nor is it HLA-DQ restricted: possible relation to increased body mass index.
Diabetologia - 1 Jan 2001
Weets I, Van Autreve J, Van der Auwera B J, Schuit F C, Du Caju M V, Decochez K, De Leeuw I H, Keymeulen B, Mathieu C, Rottiers R, Dorchy H, Quartier E, Gorus F K
Abstract excerpt
UNLABELLED: AIMS/HYPOTHESIS. We investigated whether the reported HLA-DQ/DR restricted male-to-female (M:F) excess in Type I (insulin-dependent) diabetes mellitus also exists in Belgian patients, is specific for immune-mediated diabetes, remains genotype-restricted after adjustment for age at diagnosis, and is associated with sex-dependent environmental factors. METHODS: Autoantibodies, HLA-DQ and 5'INS...
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