Article
Insulin autoantibodies and high titre islet cell antibodies are preferentially associated with the HLA DQA1*0301-DQB1*0302 haplotype at clinical type 1 (insulin-dependent) diabetes mellitus before age 10 years, but not at onset between age 10 and 40 years. The Belgian Diabetes Registry.
Diabetologia - 1 Nov 1993
Vandewalle C L, Decraene T, Schuit F C, De Leeuw I H, Pipeleers D G, Gorus F K
Abstract excerpt
Demographic and biological data were collected from all Caucasian Type 1 diabetic patients (n = 279) who were recruited at clinical onset by the Belgian Diabetes Registry over 34 months. The male/female ratio was significantly higher for onset between age 20 and 40 years (2.4) than before age 20...
Topics
- Adolescent
- Adult
- Age Factors
- Age of Onset
- Autoantibodies
- Child
- Diabetes Mellitus, Type 1
- Female
- Fructosamine
- Genotype
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- HLA-DQ beta-Chains
- Haplotypes