Article
Association between an interleukin-13 promoter polymorphism and atopy.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Oct 2003
Hummelshoj T, Bodtger U, Datta P, Malling H J, Oturai A, Poulsen L K, Ryder L P, Sorensen P S, Svejgaard E, Svejgaard A
Abstract excerpt
Several studies indicate genetic involvement of Th2 cytokines in allergic diseases. Interleukin (IL)-13 has been mapped to the cytokine cluster on chromosome 5q31-33, which has been associated with atopic conditions. Recently, an association was reported between the T allele in a promoter polymorphism in the IL-13 gene (C to T exchange) at position -1055 and allergic asthma in a population study in the...
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