The hTERTα Splice Variant is a Dominant Negative Inhibitor of Telomerase Activity

Abstract excerpt

The telomerase catalytic subunit (hTERT) is an essential component of the holoenzyme complex that adds telomeric repeats to the ends of human chromosomes. Maintenance of telomeres by telomerase or another mechanism is required for cell immortalization, and loss of telomeric DNA has been proposed as a trigger for cellular senescence. Available evidence suggests that regulation of telomerase activity primarily...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to DNA Repair Mechanisms
• Share to Microplastics and Plastic Pollution
• Share to Telomeres, Telomerase, and Senescence