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Article

Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells

1 Dec 2001

Abstract excerpt

Telomerase is a reverse transcriptase that adds telomeric repeats to chromosomal ends. In most normal human somatic cells, telomerase is repressed and telomeres progressively shorten, leading to limited proliferative life-span. Telomerase reactivation is associated with cellular immortalization and is a frequent event during tumorigenesis. The telomerase ribonucleoprotein complex consists of two essential...

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PMID: 11726691
DOI: 10.1093/nar/29.23.4818

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