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Article

A humanized anti--4-1BB monoclonal antibody suppresses antigen-induced humoral immune response in nonhuman primates.

Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 2000

Hong H J, Lee J W, Park S S, Kang Y J, Chang S Y, Kim K M, Kim J O, Murthy K K, Payne J S, Yoon S K, Park M J, Kim I C, Kim J G, Kang C Y

Abstract excerpt

The interaction of 4-1BB and its ligand plays an important role in the regulation of T-cell-mediated immune responses. In this study, the authors examined the effect of a humanized anti--4-1BB monoclonal antibody (H4B4) on ovalbumin-induced immune responses in baboons. Previously, a mouse monoclonal antibody, 4B4 against the human 4-1BB molecule, was generated and characterized. Based on this antibody, a...

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Identifiers

PMID: 11186149
DOI: 10.1097/00002371-200011000-00002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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