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Article

Generation and characterization of a human monoclonal autoantibody that acts as a high affinity interleukin-1 alpha specific inhibitor.

Molecular immunology - 1 Jan 2000

Garrone P, Djossou O, Fossiez F, Reyes J, Ait-Yahia S, Maat C, Ho S, Hauser T, Dayer J M, Greffe J, Miossec P, Lebecque S, Rousset F, Banchereau J

Abstract excerpt

Interleukin-1 (IL-1) defines two polypeptides, IL-1 alpha and IL-1 beta, that possess a wide spectrum of biological effects. Two natural antagonists of IL-1 action have been characterized: the IL-1 receptor antagonist (IL-1Ra) and a soluble form of the type II IL-1 receptor. Neutralizing autoantibodies to IL-1 alpha have also been detected in sera of healthy individuals and patients with autoimmune or...

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PMID: 8760277
DOI: 10.1016/0161-5890(96)00017-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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