Article
Generation and characterization of a human monoclonal autoantibody that acts as a high affinity interleukin-1 alpha specific inhibitor.
Molecular immunology - 1 Jan 2000
Garrone P, Djossou O, Fossiez F, Reyes J, Ait-Yahia S, Maat C, Ho S, Hauser T, Dayer J M, Greffe J, Miossec P, Lebecque S, Rousset F, Banchereau J
Abstract excerpt
Interleukin-1 (IL-1) defines two polypeptides, IL-1 alpha and IL-1 beta, that possess a wide spectrum of biological effects. Two natural antagonists of IL-1 action have been characterized: the IL-1 receptor antagonist (IL-1Ra) and a soluble form of the type II IL-1 receptor. Neutralizing autoanti...
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Antibody Affinity
- Antibody Specificity
- Autoantibodies
- B-Lymphocytes
- Base Sequence
- Binding, Competitive
- Cell Line
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Light Chains
- Immunoglobulin Variable Region