Article
Glutathione S-transferase M1 gene deletion may be associated with susceptibility to certain forms of schizophrenia.
Biochemical and biophysical research communications - 23 Feb 2001
Harada S, Tachikawa H, Kawanishi Y
Abstract excerpt
Recent studies have revealed that GSTM1 and M2 of the mu-class glutathione S-transferases catalyze a glutathione conjugate of catechol o-quinones including dopachrome, noradrenochrome, and adrenochrome under physiological conditions. Reduced or negative levels of activity amongst these enzymes would lead to an excess of neurotoxic compounds of catecholamine o-quinones. A defect in the mechanisms responsible for...
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