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Association study between the genetic polymorphisms of glutathione‐related enzymes and schizophrenia in a Japanese population

30 Apr 2008

Abstract excerpt

Several lines of evidence suggest that oxidative stress plays a role in the pathogenesis of schizophrenia, and that glutathione (GSH) plays a crucial role in antioxidant defense mechanisms. In this study, we performed association studies between GSH-related genes (GSTM1, GSTP1, GSTO1, GSTT1, GSTT2, GPX1, and GCLM) and schizophrenia in a Japanese population. The overall distributions of the genotypes and alleles...

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PMID: 18449862
DOI: 10.1002/ajmg.b.30776

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