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Article

Requirement of the Lec35 gene for all known classes of monosaccharide-P-dolichol-dependent glycosyltransferase reactions in mammals.

Molecular biology of the cell - 1 Feb 2001

Anand M, Rush J S, Ray S, Doucey M A, Weik J, Ware F E, Hofsteenge J, Waechter C J, Lehrman M A

Abstract excerpt

The Lec35 gene product (Lec35p) is required for utilization of the mannose donor mannose-P-dolichol (MPD) in synthesis of both lipid-linked oligosaccharides (LLOs) and glycosylphosphatidylinositols, which are important for functions such as protein folding and membrane anchoring, respectively. The hamster Lec35 gene is shown to encode the previously identified cDNA SL15, which corrects the Lec35 mutant phenotype...

Topics

Acyclic Monoterpenes
Animals
Bacterial Proteins
CHO Cells
Carbohydrate Sequence
Cell Membrane Permeability
Chromosomes, Human, Pair 17
Cricetinae
Dolichol Monophosphate Mannose
Exons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Glycolipids

Glycosylation

Glycosyltransferases

Humans

Lipid Metabolism

Lipids

Mammals

Molecular Sequence Data

Source

Open in PubMed Open full text

Identifiers

PMID: 11179430
DOI: 10.1091/mbc.12.2.487
PMCID: PMC30958

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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