Article
New phenotype of mutations deficient in glucosylation of the lipid-linked oligosaccharide: cloning of the ALG8 locus.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jun 1994
Stagljar I, te Heesen S, Aebi M
Abstract excerpt
Glc3Man9GlcNAc2 is the preferred substrate of the oligosaccharyltransferase of N-linked glycosylation of proteins, but nonglucosylated oligosaccharides can be transferred to proteins in Saccharomyces cerevisiae. Mutations affecting the addition of the three terminal glucose residues lead to accum...
Topics
- Amino Acid Sequence
- Base Sequence
- Carbohydrate Sequence
- Cloning, Molecular
- Fungal Proteins
- Genes, Fungal
- Glucosyltransferases
- Glycosylation
- Hexosyltransferases
- Lipopolysaccharides
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Oligosaccharides
- Open Reading Frames
- Phenotype
- Restriction Mapping
- Saccharomyces cerevisiae