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Article

A specific screen for oligosaccharyltransferase mutations identifies the 9 kDa OST5 protein required for optimal activity in vivo and in vitro.

The EMBO journal - 17 Mar 1997

Reiss G, te Heesen S, Gilmore R, Zufferey R, Aebi M

Abstract excerpt

The central reaction in the process of N-linked protein glycosylation in eukaryotic cells, the transfer of the oligosaccharide Glc(3)Man(9)GlcNAc(2) from the lipid dolicholpyrophosphate to selected asparagine residues, is catalyzed by the oligosaccharyltransferase (OTase). This enzyme consists of multiple subunits; however, purification of the complex has revealed different results with respect to its protein...

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Identifiers

PMID: 9135133
DOI: 10.1093/emboj/16.6.1164
PMCID: PMC1169715

Genes

WBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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A specific screen for oligosaccharyltransferase mutations identifies the 9 kDa OST5 protein required for optimal activity in vivo and in vitro.PMID 9135133Read ↗

The STT3 protein is a component of the yeast oligosaccharyltransferase complex.Semantic proximity Read ↗

The oligosaccharyltransferase complex from Saccharomyces cerevisiae. Isolation of the OST6 gene, its synthetic interaction with OST3, and analysis of the native complex.Semantic proximity Read ↗

STT3, a highly conserved protein required for yeast oligosaccharyl transferase activity in vivo.Semantic proximity Read ↗

Studies on the N-glycosylation of the subunits of oligosaccharyl transferase in Saccharomyces cerevisiae.Semantic proximity Read ↗

Biochemistry, molecular biology, and genetics of the oligosaccharyltransferase.Semantic proximity Read ↗

Studies on the role of the hydrophobic domain of Ost4p in interactions with other subunits of yeast oligosaccharyl transferase.Semantic proximity Read ↗

The OST4 gene of Saccharomyces cerevisiae encodes an unusually small protein required for normal levels of oligosaccharyltransferase activity.Semantic proximity Read ↗

Insight into functional aspects of Stt3p, a subunit of the oligosaccharyl transferase. Evidence for interaction of the N-terminal domain of Stt3p with the protein kinase C cascade.Semantic proximity Read ↗

Cellular Consequences of Diminished Protein O-Mannosyltransferase Activity in Baker's Yeast.Semantic proximity Read ↗

A specific segment of the transmembrane domain of Wbp1p is essential for its incorporation into the oligosaccharyl transferase complex.Semantic proximity Read ↗

Specialized roles of the conserved subunit OST3/6 of the oligosaccharyltransferase complex in innate immunity and tolerance to abiotic stresses.Semantic proximity Read ↗

Determination of the membrane topology of Ost4p and its subunit interactions in the oligosaccharyltransferase complex in Saccharomyces cerevisiae.Semantic proximity Read ↗

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