Article
Prespliceosomal assembly on microinjected precursor mRNA takes place in nuclear speckles.
Molecular biology of the cell - 1 Feb 2001
Melcák I, Melcáková S, Kopský V, Vecerová J, Raska I
Abstract excerpt
Nuclear speckles (speckles) represent a distinct nuclear compartment within the interchromatin space and are enriched in splicing factors. They have been shown to serve neighboring active genes as a reservoir of these factors. In this study, we show that, in HeLa cells, the (pre)spliceosomal assembly on precursor mRNA (pre-mRNA) is associated with the speckles. For this purpose, we used microinjection of splicing...
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