Article
Perispeckles are major assembly sites for the exon junction core complex.
Molecular biology of the cell - 1 May 2012
Daguenet Elisabeth, Baguet Aurélie, Degot Sébastien, Schmidt Ute, Alpy Fabien, Wendling Corinne, Spiegelhalter Coralie, Kessler Pascal, Rio Marie-Christine, Le Hir Hervé, Bertrand Edouard, Tomasetto Catherine
Abstract excerpt
The exon junction complex (EJC) is loaded onto mRNAs as a consequence of splicing and regulates multiple posttranscriptional events. MLN51, Magoh, Y14, and eIF4A3 form a highly stable EJC core, but where this tetrameric complex is assembled in the cell remains unclear. Here we show that EJC factors are enriched in domains that we term perispeckles and are visible as doughnuts around nuclear speckles. Fluorescence...
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