Article
Subnuclear localization and dynamics of the Pre-mRNA 3' end processing factor mammalian cleavage factor I 68-kDa subunit.
Molecular biology of the cell - 1 Apr 2007
Cardinale Stefano, Cisterna Barbara, Bonetti Paolo, Aringhieri Chiara, Biggiogera Marco, Barabino Silvia M L
Abstract excerpt
Mammalian cleavage factor I (CF Im) is an essential factor that is required for the first step in pre-mRNA 3' end processing. Here, we characterize CF Im68 subnuclear distribution and mobility. Fluorescence microscopy reveals that in addition to paraspeckles CF Im68 accumulates in structures that partially overlap with nuclear speckles. Analysis of synchronized cells shows that CF Im68 distribution in speckles...
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