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Article

The K+ channel signature sequence of murine Kir2.1: mutations that affect microscopic gating but not ionic selectivity.

The Journal of physiology - 15 Feb 2001

So I, Ashmole I, Davies N W, Sutcliffe M J, Stanfield P R

Abstract excerpt

1. We have studied the effects on ionic selectivity and gating of Kir2.1 of replacing Tyr (Y) in the GYG signature sequence with Phe (Y145F), Leu (Y145L), Met (Y145M), Ala (Y145A) or Val (Y145V). 2. The mutant Y145F showed no changes in ionic selectivity (as indicated by the permeability coefficient ratios PNa/PK or PRb/PK), indicating that a hydrogen bond between Tyr and other residues is not essential for K+...

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Identifiers

PMID: 11179390
DOI: 10.1111/j.1469-7793.2001.0037j.x
PMCID: PMC2278438

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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