Potassium channel gating in the absence of the highly conserved glycine of the inner transmembrane helix.

Abstract excerpt

Potassium channel activation regulates cellular excitability, such as in neuronal and cardiac cells. Regulation of ion channel activity relies on a switching mechanism between two major conformations, the open and closed states, known as gating. It has been suggested that potassium channels are generally gated via a pivoted mechanism the pore-lining helix (TM2) in the proximity of a glycine that is conserved in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Asparagine
• Share to G Protein-Coupled Inwardly-Rectifying Potassium Channels