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Article

Mutations in the K+ channel signature sequence.

Biophysical journal - 1 Apr 1994

Heginbotham L, Lu Z, Abramson T, MacKinnon R

Abstract excerpt

Potassium channels share a highly conserved stretch of eight amino acids, a K+ channel signature sequence. The conserved sequence falls within the previously defined P-region of voltage-activated K+ channels. In this study we investigate the effect of mutations in the signature sequence of the Shaker channel on K+ selectivity determined under bi-ionic conditions. Nonconservative substitutions of two threonine...

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Identifiers

PMID: 8038378
DOI: 10.1016/S0006-3495(94)80887-2
PMCID: PMC1275813

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutations in the K+ channel signature sequence.PMID 8038378Read ↗

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A point mutation in a Shaker K+ channel changes its charybdotoxin binding site from low to high affinity.Semantic proximity Read ↗

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