Article
Mutations in the K+ channel signature sequence.
Biophysical journal - 1 Apr 1994
Heginbotham L, Lu Z, Abramson T, MacKinnon R
Abstract excerpt
Potassium channels share a highly conserved stretch of eight amino acids, a K+ channel signature sequence. The conserved sequence falls within the previously defined P-region of voltage-activated K+ channels. In this study we investigate the effect of mutations in the signature sequence of the Sh...
Topics
- Amino Acid Sequence
- Animals
- Biophysical Phenomena
- Biophysics
- Conserved Sequence
- Drosophila
- Female
- In Vitro Techniques
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Oocytes
- Phenotype
- Potassium
- Potassium Channels
- Sequence Homology, Amino Acid
- Xenopus laevis