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Human Neutrophils and Their Products Induce Shiga Toxin Production by Enterohemorrhagic <i>Escherichia coli</i>

1 Mar 2001

Abstract excerpt

The Shiga toxins (Stx) are critical virulence factors for Escherichia coli O157:H7 and other serotypes of enterohemorrhagic E. coli (EHEC). These potent toxins are encoded in the genomes of temperate lambdoid bacteriophages. We recently demonstrated that induction of the resident Stx2-encoding prophage in an O157:H7 clinical isolate is required for toxin production by this strain. Since several factors produced...

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PMID: 11179378
DOI: 10.1128/iai.69.3.1934-1937.2001

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