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Nitric oxide inhibits Shiga-toxin synthesis by enterohemorrhagic <i>Escherichia coli</i>

30 May 2007

Abstract excerpt

Shiga-toxin (Stx) is the cardinal virulence factor of enterohemorrhagic Escherichia coli (EHEC). The genes encoding Stx are carried by a lambdoid phage integrated in the bacterial genome and are fully expressed after a bacterial SOS response induced by DNA-damaging agents. Because nitric oxide (NO) is an essential mediator of the innate immune response of infected colonic mucosa, we aimed to determine its role in...

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PMID: 17537918
DOI: 10.1073/pnas.0702589104

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