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Molecular Biology of Escherichia coli Shiga Toxins’ Effects on Mammalian Cells

23 May 2020

Abstract excerpt

(STEC). EHEC strains, e.g., strains of serovars O157:H7 and O104:H4, may cause individual cases as well as large outbreaks of life-threatening diseases in humans. Stxs primarily exert a ribotoxic activity in the eukaryotic target cells of the mammalian host resulting in rapid protein synthesis inhibition and cell death. Damage of endothelial cells in the kidneys and the central nervous system by Stxs is central...

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PMID: 32456125
DOI: 10.3390/toxins12050345

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