Genetic and Epigenetic Associations with Pre–Chronic Obstructive Pulmonary Disease Lung Function Trajectories

Abstract excerpt

Understanding the molecular mechanisms of lung function trajectories that progress to chronic obstructive pulmonary disease (COPD) (pre-COPD trajectories), especially those with a rapidly declining phenotype, should inform preventive interventions. The Tasmanian Longitudinal Health Study (TAHS) previously defined life-course lung function trajectories by serial spirometry in a cohort of all seven-year-old school...

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