Article
Genetic variants of microsomal epoxide hydrolase and glutamate-cysteine ligase in COPD.
The European respiratory journal - 1 Oct 2008
Chappell S, Daly L, Morgan K, Guetta-Baranes T, Roca J, Rabinovich R, Lotya J, Millar A B, Donnelly S C, Keatings V, MacNee W, Stolk J, Hiemstra P S, Miniati M, Monti S, O'Connor C M, Kalsheker N
Abstract excerpt
The genetic factors that contribute to the development of chronic obstructive pulmonary disease (COPD) are poorly understood. Many candidate genes have been proposed, including enzymes that protect the lung against oxidative stress, such as microsomal epoxide hydrolase (EPHX1) and glutamate-cysteine ligase (GCL). To date, most reported findings have been for EPHX1, particularly in relation to functional variants...
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