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Article

Role of Apoptosis and Apoptosis-Related Genes in Cellular Response and Antitumor Efficacy of Anthracyclines

1 Jan 2001

Abstract excerpt

Cellular resistance to anthracyclines is a major limitation of their clinical use in the treatment of human tumors. Resistance to doxorubicin is described as a multifactorial phenomenon involving the overexpression of defense factors and alterations in drug-target interactions. Such changes do not account for all manifestations of drug resistance, in particular intrinsic resistance of solid tumors. Since...

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PMID: 11172690
DOI: 10.2174/0929867013373994

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Source receipt: pubmed, retrieved 7 Sept 2026.

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