Article
Pleiotropic drug resistance and survival advantage in leukemic cells with diminished apoptotic response.
International journal of cancer - 15 Oct 1994
Frankfurt O S, Seckinger D, Sugarbaker E V
Abstract excerpt
Cell line R9 generated by continuous exposure of MOLT-4 cells to adriamycin was cross-resistant to a variety of unrelated drugs. The following data indicate that diminished apoptotic response was the mechanism of acquired pleiotropic drug resistance: (i) apoptosis was a common mechanism of cell d...
Topics
- Antineoplastic Agents
- Apoptosis
- Cell Division
- Cell Membrane Permeability
- Cell Survival
- Doxorubicin
- Drug Resistance, Multiple
- Humans
- Kinetics
- Leukemia, Lymphoid
- Microscopy, Fluorescence
- Phenotype
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2
- Rhodamine 123
- Rhodamines