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Article

Pleiotropic drug resistance and survival advantage in leukemic cells with diminished apoptotic response.

International journal of cancer - 15 Oct 1994

Frankfurt O S, Seckinger D, Sugarbaker E V

Abstract excerpt

Cell line R9 generated by continuous exposure of MOLT-4 cells to adriamycin was cross-resistant to a variety of unrelated drugs. The following data indicate that diminished apoptotic response was the mechanism of acquired pleiotropic drug resistance: (i) apoptosis was a common mechanism of cell death for agents expressing cross-resistance; (ii) induction of apoptosis by drugs, medium depletion and serum...

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Identifiers

PMID: 7927923
DOI: 10.1002/ijc.2910590214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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